Grilled Chicken Spinach Panini

Featured in: Quick Weeknight Dinners

This Italian-American panini combines tender grilled chicken breast, fresh baby spinach, and a blend of mozzarella and Parmesan cheese, all enhanced with aromatic garlic butter. The bread is pressed until golden, creating a crispy exterior while keeping the filling warm and melty inside.

Perfect for lunch or dinner, this sandwich comes together in just 30 minutes. Grill the chicken with Italian herbs, prepare the garlic butter spread, layer your ingredients, and press until golden. Serve with a simple salad or tomato soup for a complete meal.

Updated on Sun, 18 Jan 2026 15:49:00 GMT
Golden-brown Grilled Chicken Spinach Panini oozing with melted mozzarella, layered with fresh spinach on crusty sourdough. Save
Golden-brown Grilled Chicken Spinach Panini oozing with melted mozzarella, layered with fresh spinach on crusty sourdough. | whisknjoy.com

My neighbor knocked on my door one Tuesday afternoon with a panini press she didn't want anymore. I wasn't sure I'd use it, but by that weekend I was hooked. The first sandwich I made was this grilled chicken panini, and the smell of garlic butter hitting hot bread filled my kitchen in a way that felt both comforting and exciting. Now it's my go-to whenever I want something hearty that doesn't require much fuss.

I made these panini for my brother after he helped me move furniture, and he ate two in one sitting without saying a word until they were gone. He just looked up and asked if there was more chicken in the fridge. That's when I knew this recipe was a keeper. It's become my unofficial thank you meal ever since.

Ingredients

  • Boneless, skinless chicken breasts: These grill up tender and slice beautifully for layering, and I always let them rest so the juices don't run out when I cut them.
  • Olive oil: Brushing the chicken with this before grilling keeps it moist and adds a subtle richness that pairs well with the herbs.
  • Salt, black pepper, and dried Italian herbs: This simple seasoning blend is all the chicken needs to taste flavorful without overpowering the garlic butter.
  • Unsalted butter: Softened butter is key because it spreads easily and lets you control the salt level in the garlic mix.
  • Garlic cloves: Fresh minced garlic makes all the difference, the jarred stuff just doesn't give you that punch of flavor.
  • Fresh parsley: It adds a hint of brightness to the butter and makes the whole thing feel a little more special.
  • Rustic Italian or sourdough bread: Sturdy bread holds up to pressing and doesn't get soggy, plus it crisps up perfectly on the outside.
  • Fresh baby spinach: I use baby spinach because it's tender and wilts just enough without making the sandwich watery.
  • Shredded mozzarella cheese: This melts into gooey perfection and holds everything together beautifully.
  • Grated Parmesan cheese: It adds a salty, nutty layer that balances the mildness of the mozzarella.

Instructions

Preheat the grill:
Get your grill pan or outdoor grill nice and hot over medium-high heat so the chicken gets those lovely char marks. You want to hear a sizzle when the chicken hits the grates.
Season and grill the chicken:
Brush the chicken breasts with olive oil and sprinkle them with salt, pepper, and Italian herbs, then grill for 5 to 6 minutes per side until they're cooked through and no longer pink inside. Let them rest for 5 minutes before slicing thinly so all the juices stay inside.
Make the garlic butter:
In a small bowl, mix the softened butter with minced garlic and chopped parsley until it's smooth and fragrant. This step smells so good you'll want to spread it on everything.
Prepare the bread:
Lay out your bread slices on a clean surface and spread the garlic butter on one side of each slice. The buttered side will face out when you assemble the sandwiches.
Assemble the panini:
On the unbuttered side of 4 bread slices, layer the sliced grilled chicken, a handful of spinach, mozzarella, and Parmesan, then top with the remaining bread slices with the buttered side facing out. Press down gently so everything sticks together a bit.
Grill the panini:
Heat your panini press or a large skillet over medium heat, then place the sandwiches in and press down (if using a skillet, weigh them down with a heavy pan). Cook for 3 to 5 minutes per side until the bread is golden brown and the cheese is melted and oozing.
Serve hot:
Slice each panini in half and serve immediately while the cheese is still gooey. The crunch of the bread against the soft, warm filling is what makes this so satisfying.
Savory Grilled Chicken Spinach Panini served hot, revealing juicy chicken and melted cheese in each bite. Save
Savory Grilled Chicken Spinach Panini served hot, revealing juicy chicken and melted cheese in each bite. | whisknjoy.com

One rainy afternoon, I made these panini for myself and sat by the window with a cup of soup. The sound of the rain mixed with the crunch of the bread, and I realized sometimes the best meals are the ones you make just for you. It reminded me that good food doesn't need an occasion.

Choosing Your Bread

I've tried this recipe with all kinds of bread, and sourdough always wins for flavor, but ciabatta works beautifully if you want something airier. Avoid soft sandwich bread because it just can't handle the heat and weight of a panini press. The crust should be sturdy enough to crisp up without crumbling, and the inside should have enough chew to soak up a little garlic butter without getting mushy.

Make It Your Own

Once you've made this a few times, you'll start seeing all the ways you can change it up. I've added roasted red peppers, swapped provolone for mozzarella, and even tucked in a few sun-dried tomatoes when I had them sitting in the fridge. My friend uses turkey instead of chicken and says it's just as good. The garlic butter and the press are what make it a panini, everything else is flexible.

Storing and Reheating

If you have leftovers, wrap them tightly in foil and store them in the fridge for up to two days. Reheat them in a skillet over low heat or in the oven at 350°F until warmed through, the microwave will make the bread soggy and you'll lose that crispy texture. I usually make extra chicken so I can throw together another panini the next day without any extra work.

  • Let the sandwiches cool completely before wrapping to avoid steam buildup.
  • Reheat in a dry skillet for the best texture.
  • You can freeze the grilled chicken separately and assemble fresh panini anytime.
Close-up of a Grilled Chicken Spinach Panini with crispy edges, garlic butter, and vibrant green spinach. Save
Close-up of a Grilled Chicken Spinach Panini with crispy edges, garlic butter, and vibrant green spinach. | whisknjoy.com

This panini has become one of those recipes I turn to when I want comfort without complication. It's warm, satisfying, and always tastes like I put in more effort than I actually did.

Recipe FAQ

Can I prepare the chicken in advance?

Yes, you can grill the chicken up to 2 days ahead and store it in the refrigerator. Simply reheat it gently before assembling your panini, or use it cold if preferred.

What cheese works best for this panini?

Mozzarella and Parmesan are excellent choices for melting and flavor. Provolone is a great alternative that adds a slightly sharper taste. Avoid cheeses that don't melt well.

Can I use a regular skillet instead of a panini press?

Absolutely. Place the panini in a heated skillet over medium heat, then use a heavy pan or cast iron skillet on top to press it down. Cook until the bread is golden and cheese melts through.

What are good side dishes to serve with this panini?

A simple green salad with vinaigrette, tomato soup, roasted vegetables, or crispy potato chips pair wonderfully. The light sides balance the richness of the melted cheese and butter.

How can I make this panini vegetarian?

Replace the chicken with roasted vegetables like zucchini, eggplant, or portobello mushrooms. Grill or roast them until tender, then layer with the spinach, cheese, and garlic butter as directed.

Grilled Chicken Spinach Panini

Warm and savory panini with grilled chicken, spinach, melty cheese, and garlic butter on crusty bread pressed to golden perfection.

Prep duration
15 min
Cook duration
15 min
Complete duration
30 min
Created by Sophia Turner

Classification Quick Weeknight Dinners

Skill Level Easy

Cultural Background Italian-American

Output 4 Portion Count

Dietary considerations None specified

Components

Chicken

01 2 boneless, skinless chicken breasts
02 1 tablespoon olive oil
03 1/2 teaspoon salt
04 1/2 teaspoon black pepper
05 1/2 teaspoon dried Italian herbs

Garlic Butter

01 3 tablespoons unsalted butter, softened
02 2 cloves garlic, minced
03 1 tablespoon fresh parsley, finely chopped

Panini Assembly

01 8 slices rustic Italian or sourdough bread
02 2 cups fresh baby spinach, washed and dried
03 1.5 cups shredded mozzarella cheese or provolone
04 0.5 cup grated Parmesan cheese
05 Olive oil for brushing

Preparation Steps

Stage 01

Heat Grill Surface: Preheat a grill pan or outdoor grill to medium-high heat.

Stage 02

Prepare and Grill Chicken: Brush chicken breasts with olive oil and season with salt, pepper, and Italian herbs. Grill for 5-6 minutes per side until cooked through. Allow to rest for 5 minutes, then slice thinly.

Stage 03

Prepare Garlic Butter Spread: Combine softened butter, minced garlic, and finely chopped parsley in a small bowl and mix thoroughly.

Stage 04

Assemble Bread Foundation: Arrange bread slices on a work surface and spread garlic butter mixture on one side of each slice.

Stage 05

Layer Panini Fillings: On the unbuttered side of 4 bread slices, layer sliced grilled chicken, fresh spinach, mozzarella cheese, and Parmesan cheese. Top with remaining bread slices with buttered side facing outward.

Stage 06

Cook Panini: Heat a panini press or large skillet over medium heat. Place assembled sandwiches in the press or skillet with a heavy pan to weigh down. Cook 3-5 minutes per side until bread achieves golden color and cheese melts completely.

Stage 07

Finish and Serve: Slice panini diagonally in half and serve immediately while hot.

Necessary tools

  • Grill pan or outdoor grill
  • Panini press or large skillet
  • Mixing bowl
  • Chef's knife and cutting board

Allergy details

Review all ingredients for potential allergens and consult with healthcare professionals if you're unsure about any item.
  • Contains wheat from bread
  • Contains milk from cheese and butter
  • May contain traces of gluten depending on bread brand
  • May contain traces of dairy depending on cheese brand

Nutritional content (each portion)

These values are provided as estimates only and shouldn't replace professional medical guidance.
  • Energy: 450
  • Fats: 20 g
  • Carbohydrates: 35 g
  • Proteins: 32 g